Early detection of cognitive decline from speech offers a scalable and non-invasive alternative to conventional clinical assessment. Verbal fluency tasks are particularly informative, but most automated approaches aggregate features across an entire recording, overlooking temporal speech dynamics. We propose the Cognitive Instability-Aware Cross-Modal Attention Network (CCMAN), a transfer learning framework that learns task-agnostic cognitive speech representations from multiple memory-probing tasks before fine-tuning on a minute-long semantic and phonemic verbal fluency task. CCMAN integrates semantic, acoustic, and linguistic information through bidirectional cross-attention, gated multimodal fusion, and transformer-based temporal modelling to derive interpretable biomarkers of cognitive decline. Experiments were conducted on 165.44 hours of speech from 843 participants (498 healthy controls, 245 with mild cognitive impairment, and 100 with dementia). CCMAN achieved Macro-F1 scores of 0.81 and 0.59 for binary and multiclass semantic fluency classification, and 0.77 and 0.53 for phonemic fluency, consistently outperforming strong static and temporal baselines. Statistical analyses showed that semantic drift variance and pause variance, but not mean semantic drift, were significantly elevated in both MCI and dementia relative to healthy controls, while pause duration increased progressively over the task with the steepest slope in dementia, supporting global and progressive temporal speech instability as interpretable biomarkers. Evaluation on the independent PROCESS-2 benchmark further demonstrated the generalisability of the proposed framework, improving the baseline Macro-F1 by up to 9%. These findings support temporal speech instability as a dynamic speech biomarker for robust, interpretable, and generalisable early detection of cognitive decline.
https://arxiv.org/abs/2609.14764
Subtomogram classification in cryo-electron tomography (cryo-ET) is a challenging problem due to the scarcity of labeled examples. While cryo-ET simulators can be adopted to generate unlimited synthetic data, the substantial domain gap between synthetic and real subtomograms hinders its practical utilization. In this work, we propose a novel synthetic-to-real adaptation framework with a learnable transformation module, bridging this gap at both the input and feature levels. Extensive experiments demonstrate that our method consistently outperforms existing transfer learning baselines in few-shot settings.
https://arxiv.org/abs/2609.14097
Facial emotion recognition (FER) in real-world environments remains challenging due to unconstrained imaging conditions, including multiple faces, occlusions, pose variations, and complex lighting. Most existing studies focus on individual facial emotion classification and do not address the analysis of collective emotional states at the event level. This paper proposes an end-to-end pipeline for event-level emotion recognition from photographs. The approach detects faces in each image, classifies facial expressions using a deep convolutional neural network, and aggregates face-level emotion probabilities to estimate the overall emotional distribution of a public event. A comparative evaluation of several CNN architectures on the FER- 2013 and RAF-DB datasets demonstrates that transfer learning with EfficientNet-B2 trained on RAF-DB is more suitable for real-world RGB data. The proposed method is evaluated on a real-world event dataset containing 1658 images. Experimental results show stable emotion distributions across event subsets, confirming the effectiveness of event-level aggregation for emotion analysis in the wild.
https://arxiv.org/abs/2609.13854
Deep learning on cortical surfaces faces a dilemma: capturing the complex topology of over 60 nomenclature-dependent sulci per hemisphere requires high-capacity models, yet the extreme scarcity of expert annotations ($N=62$ subjects) inevitably causes overfitting. Standard supervised approaches fail to generalize in this data-scarce regime, particularly for variable and small sulci where topological ambiguity is high. To overcome this limitation, we introduce a Geometric-to-Semantic Spherical Transfer Learning framework. First, we leverage massive unlabeled data (UK Biobank, $\approx$30,000 subjects) to pre-train a spherical encoder using a locally-optimized strategy. By relying solely on continuous surface features (curvature and depth), the relevance of this pre-training is confirmed by the model's ability to detect localized and rare topological traits, such as sulcal interruptions. The downstream labeling task, however, introduces extracted sulcal fundi (lines) as an explicit semantic input. To bridge this dimensional domain gap (from purely geometric to semantic) without causing catastrophic forgetting, these anatomical lines are integrated into the pre-trained backbone via a soft-initialized Topological Prior Injector. Our experiments demonstrate that this approach outperforms fully supervised baselines trained from scratch, achieving a mean Dice of 0.77. Crucially, a local analysis reveals that the self-supervised geometric priors yield the largest performance gains on variable and tertiary sulci (up to 14.8%), confirming that learning the cortex shape is highly beneficial for identifying its rarest parts.
https://arxiv.org/abs/2609.12627
Out-of-distribution length generalization, namely to extrapolate a task from short to longer context, has been studied intensively for transformers. Here we focus on distance generalization, which probes performance when inter-token distances are changed between training and inference, while keeping a fixed context length. We construct two synthetic delay copy tasks, both involving finite distances between source and recall, where tokens are copied either fully or selectively, and test models on delays unseen during training. We address three questions: (A) Do positional encoding schemes such as RoPE and ALiBi improve distance resolution relative to no positional encoding (NoPE)? (B) How does data diversity, the number of inter-token distances seen in training, affect performance? (C) When is distance transfer learning positive or negative? We present a thorough investigation, finding that it is paramount to improve our understanding of the underlying mechanisms.
https://arxiv.org/abs/2609.11913
Lung cancer is one of the leading causes of death worldwide, and its early diagnosis is crucial to improving patients prognosis and quality of life. However, the process of interpreting medical images for the detection of lung cancer is complex and requires trained experts. In this context, artificial intelligence (AI) and deep learning (DL) emerge as potential tools to automate and optimize image analysis. The objective of this work is to review the most recent and relevant applications of AI and DL in the field of radiology for the detection of lung cancer. To this end, an exhaustive search was carried out in scientific databases such as PubMed,IEEEXPLORE, Scopus and Web of Science, and 96 articles published from 2015 to the present addressing the use of AI and DL in biomedical engineering were selected. Emphasis is placed on the use of convolutional neural networks (CNN) with transfer learning and Data Augmentation as promising techniques to improve the accuracy and efficiency of the image interpretation process. The results show that the use of AI and DL can offer an effective alternative for the early diagnosis of lung cancer, with high sensitivity and specificity. However, current limitations and challenges that must be addressed to guarantee its responsible and safe application in clinical practice are also identified, such as the lack of standardized data, the ex plainability of the models, patient privacy, and the ethical and social implications. It is concluded that the use of AI and DL can have a positive impact on the care of patients with lung cancer, but further research and regulation are required to ensure its quality and reliability.
https://arxiv.org/abs/2609.10652
Ensuring effective transfer learning for vision-language models without compromising their generalization performance is crucial. However, many existing methods overlook data characteristics and simply reuse the training strategies adopted during pre-training. Specifically, they treat same-class samples as distinct instances and transform images independently of their paired text prompts, which makes model learning more difficult. We address these limitations through transformation-aware prompt conditioning and a re-calibrated contrastive loss. Fixed text descriptors identify the transformations applied to paired images, providing transformation-level consistency without altering class semantics. This design aligns the image and text branches at the transformation level, enabling richer representations while preserving the models' ability to generalize. In addition, our loss function mitigates positive-gradient dilution in soft-target cross-entropy when each anchor has multiple valid positives. During transfer, our approach treats same-class samples as positives rather than distinct instances, enabling the model to learn domain-specific features more effectively. Experiments across distribution shift, transfer learning, and few-shot settings demonstrate consistent improvements over existing approaches. Source code for our method is available at this https URL.
https://arxiv.org/abs/2609.06967
Environmental identification in wireless sensing is essential for 6G integrated sensing and communication (ISAC) systems to achieve reliable situational awareness. However, deep learning (DL) models for this task often fail to generalize under domain shift across diverse environments. While the Inter-Instance Variational Auto-encoder (IIns-VAE) learns features of rich representation, its neural classifier remains vulnerable to these distribution changes. In this paper, we propose IIns-VAE+, a hybrid model that combines the IIns-VAE framework with Minimax Risk Classifiers (MRC) to improve adaptability in transfer learning scenarios. We use real-world datasets to evaluate our framework across three transfer learning scenarios, including general to specific room environments, high to low label resolutions, and mixed to specific environments. The experimental results indicate that IIns-VAE+ significantly outperforms baselines, demonstrating its critical value in building adaptable and robust perceptive networks in future 6G systems.
https://arxiv.org/abs/2609.06131
When there is not enough labeled data to properly train deep learning models, transfer learning can help. We still do not fully understand how effective it is in neuroimaging, especially for Alzheimer's disease research. It is also not clear if these transferred models can work on new datasets without being retrained for each specific task. We evaluate whether a compact, supervised pretrained model can serve as a reusable foundation model for downstream neuroimaging tasks. We freeze the 7.18 million weights of a 3D CNN previously trained for brain-age prediction, and adapt it to each task using Low-Rank Adaptation (LoRA), requiring only ~1% additional trainable parameters. We evaluate generalizability in six experiments. Adapting the model to classify cognitively normal versus Dementia on ADNI gave an AUC of 0.964 on held-out folds (Experiment #1). Applying that adapted model unchanged to OASIS-3, with no retraining, gave an AUC of 0.871 (Experiment #2). Reusing its output logit together with age and a cognitive score distinguished stable from progressing MCI with an AUC of 0.828 (Experiment #3). Adapting the same backbone to predict amyloid positivity from structural MRI gave an AUC of 0.804 (Experiment #4). Finally, the same approach estimated ICV-normalized hippocampal and white matter hypointensity volumes directly from the T1w image, with R^2 of 0.80 and 0.91 respectively, tasks normally addressed with much larger U-Net networks (Experiments #5 and #6). A compact model supervised on brain age can therefore serve as a reusable backbone, adapting to each task with ~1% additional parameters and transferring to an unseen cohort without any training. Our findings suggest that a carefully trained brain age model can serve as an effective foundation model for Alzheimer's related tasks, even under strict data constraints.
https://arxiv.org/abs/2609.05400
Although automatic text simplification (ATS) is critical for accessibility, its progress has not matched the rapid evolution of broader natural language processing techniques. This paper investigates the application of reinforcement learning (RL) to improve the quality of ATS for low-resource languages using Large Language Models (LLMs). The paper introduces a novel reward function, designed to guide LLMs toward a targeted simplification style with Group Relative Policy Optimization (GRPO), that combines the SARI metric with specific penalty components. The effectiveness of GRPO with this reward function is motivated and demonstrated by post-training IberianLLM-7B-Instruct on the ASSET dataset. After post-training on the English ASSET, the model's ATS performance improves on two curated Catalan benchmarks while also successfully suppressing previously observed negative behaviors. Cross-lingual transfer learning is explored by translating ASSET into Catalan and Spanish and post-training the model on each version, but these fail to show a significant improvement on the out-of-domain benchmark.
https://arxiv.org/abs/2609.04823
Modern crop breeding demands precise organ-level analysis for trait quantification, making plant point cloud segmentation (PPCS) increasingly important. However, conventional deep learning approaches rely heavily on densely annotated datasets that are labor-intensive to acquire. Unified PPCS adaptation from distribution-shifted examples with minimal additional training remains challenging. To address this, we propose PlantC2USeg, a deep transfer learning framework featuring cross-scale consistency learning to explicitly align features across spatial scales and an information-restricted decoding strategy that prevents reconstruction shortcuts and promotes robust adaptation. The resulting pre-training enables stable few-shot generalization across species and sensing conditions, while unified fine-tuning with inherited thresholds further reduces adaptation overhead. Under full supervision on Soybean3D, PlantC2USeg achieves the highest semantic IoU and instance mWCov among compared methods, at 91.91% and 94.62%. With 20 labeled samples, it leads both metrics at 89.78% and 90.27%; with only 10 samples, it retains the highest mWCov of 83.23% while achieving 83.19% IoU. Across HR3D, 10-shot transfer to tobacco, tomato, and sorghum averages 78.41% IoU and 79.42% mWCov, while 22-shot transfer to SYAU-Maize achieves the highest IoU and mRec at 92.75% and 93.51%. Furthermore, a leading category-averaged mIoU of 85.0% on ShapeNet Part demonstrates the framework's capability to handle diverse shape variations beyond agricultural domains. These results demonstrate that PlantC2USeg reduces overall adaptation effort under distribution shifts, enabling scalable plant phenotyping and transferable 3D representation learning beyond agriculture.
https://arxiv.org/abs/2609.02860
Acoustic sensing offers a promising non-intrusive approach for monitoring daily activities of older adults, yet speech privacy concerns remain a critical barrier to real-world deployment. We present a privacy firewall pipeline based on a U-Net encoder-decoder, trained entirely on synthetic data, that removes speech from ambient audio while preserving environmental sounds indicative of daily activities. Activity recognition is performed using VGGish transfer learning with an SVM classifier. Evaluated on the ESC-50 and SINS datasets across multiple speech content levels, the proposed model reduced residual speech to 0% VAD-detectable speech (Silero Voice Activity Detection) under all tested conditions, outperforming Facebook Denoiser (6.55% residual), SepFormer (36.34%) and ConvTasNet (47.21%) on ESC-50 at the 100\% speech level. On ESC-50 at 40% speech level, classification performance recovers to 85% precision and 85% recall after speech removal, compared with 81%/75% before removal and an 84%/83% speech-free baseline. Evaluation on real-world participant home recordings collected with the AudioHive app showed 0% VAD-detectable speech after processing while maintaining 76% precision and recall. The pipeline enables privacy-preserving acoustic sensing without sacrificing activity recognition performance, addressing a key obstacle to the adoption of ambient monitoring in elderly care.
https://arxiv.org/abs/2609.02376
Multi-contrast MR scans contain redundant structural information that can be leveraged during reconstruction and potentially accelerate acquisition times. This idea has inspired end-to-end guided reconstruction models, leveraging one or more contrasts to guide the reconstruction of a different contrast. However, these models require large paired multi-contrast raw datasets for training, limiting their application in low-data regimes. In this work, we propose a modular framework, namely CoSMo-RecNet, for learning guided reconstruction models in the low-data regime. At its core is a reusable multi-contrast representation based on a content/style model, which can be learned from large-scale, publicly accessible, unpaired multi-contrast image datasets, without available k-space data. Using this frozen model as a multi-contrast prior and using a set of reference contrasts, the reconstruction problem reduces to a much simpler refinement problem that can be solved by a lightweight unrolled network and thus learned from small, task-specific reconstruction datasets. We demonstrate the efficacy of CoSMo-RecNet by evaluating it on the low-field 0.3 T M4Raw dataset, showing stable reconstruction quality on decreasing the raw training data budget. CoSMo-RecNet achieved higher reconstruction quality with 5 training subjects or lower compared to a parameter-count-matched MoDL trained on 100 subjects. On a data-limited and severely out-of-distribution ultra-low-field 47 mT Halbach scanner dataset, CoSMo-RecNet was superior to other viable strategies, including classical reconstruction, transfer learning, and zero-shot reconstruction.
https://arxiv.org/abs/2609.01959
Adapting large pretrained vision models under limited data and frozen-backbone constraints remains a central challenge in transfer learning. While lightweight adapters and parameter-efficient fine-tuning methods are widely adopted, most rely on generic multilayer perceptrons or low-rank linear updates, offering limited control over the spectral and geometric structure of feature transformations. We investigate whether structured nonlinear feature lifting can improve representational alignment in frozen regimes. We introduce Quantum-Inspired Nonlinear Adapters (QINA), compact modules that perform learnable trigonometric feature lifting followed by bounded nonlinear aggregation. The design induces structured oscillatory basis functions with an explicit norm-dependent Lipschitz bound, enabling spectral reshaping of pretrained representations without increasing the receptive field or significantly expanding parameter count. Importantly, the method operates entirely within standard deep learning frameworks and does not require quantum hardware. Through systematic experiments across natural and medical imaging datasets, classification and segmentation tasks, multiple adapters and placements, and varying training budgets, we show that performance in frozen regimes is primarily representation-limited. Nonlinear lifting improves adaptation, and the proposed structured trigonometric formulation consistently outperforms identity baselines, fixed Fourier feature mappings, and parameter-matched baseline adapters. Within the evaluated frozen-backbone settings, structured spectral parameterization provides a more effective inductive bias than generic nonlinear adapters. This work highlights the importance of geometry- and spectrum-aware adaptation mechanisms for large pretrained vision models.
https://arxiv.org/abs/2609.29592
Machine learning for neglected tropical diseases is limited by data, not algorithms: public annotated image sets for leprosy (Hansen's disease) number in the hundreds, orders of magnitude below what generative models require. We ask whether a model trained on abundant chronic wound photography transfers to this low-data regime. We build a three-stage pipeline. First, a DeepLabV3-ResNet50 segmentation network (validation Dice 0.876, IoU 0.799) supplies lesion masks for two wound datasets that ship without them. Second, we assemble a mask-conditioned latent diffusion model from Stable Diffusion 1.5 components and train it on 3,280 region-of-interest wound crops, widening the UNet input convolution from 4 to 11 channels to admit three mask feature maps and a blurred low-frequency context latent. Third, we fine-tune this model on 708 leprosy image-mask pairs drawn from 764 images of approximately 150 patients. We evaluate with LPIPS perceptual distance, anchored by a real-versus-real baseline computed on the same 242 anchor images as the cross-set comparisons; without that reference the cross-set distances cannot be interpreted. The generated set shows no mode collapse: its internal perceptual diversity (0.662) is statistically indistinguishable from that of the real leprosy set (0.672, 95% CI [0.664, 0.680]). Generated images sit 0.044 LPIPS outside the real distribution - measurably apart, but under half of one standard deviation. Fine-tuning shifted the output distribution only marginally, which we trace to lesion geometry reaching the network through input concatenation alone. Chronic wound photography is therefore a viable donor domain for leprosy lesion synthesis: low-level appearance transfers well, and the remaining barrier is semantic control rather than image quality.
https://arxiv.org/abs/2609.13226
We introduce ViTAMINS, a method that integrates synthetic hard negatives into unsupervised vision transformer pretraining to improve representation quality. Our approach is thoroughly benchmarked on ImageNet and transfer learning, image retrieval, copy detection, and image, video segmentation tasks. Notably, our proposed negatives give rise to emergent properties, where learned representations contain explicit information about the semantic content of an image and serve as excellent classifiers (up to +11.3% over baselines). ViTAMINS achieves these benefits through simple modifications to existing contrastive frameworks and outperforms competing methods while being more resource efficient, e.g., our ViT-B surpasses V-JEPA with ViT-L. Our findings motivate reconsidering contrastive learning as a simpler yet powerful alternative to dominant generative and self-distillation approaches.
https://arxiv.org/abs/2609.01041
Whole-heart segmentation (WHS) in computed tomography (CT) and magnetic resonance imaging (MRI) is affected by acquisition shifts and heterogeneous cardiac annotations. Existing WHS systems combine architectural design, transfer learning, and generic spatial or intensity augmentation. We investigate whether changes to data augmentation and training supervision can improve cross-modality WHS while the segmentation architecture is held constant. We present LISynSeg, a data-centric approach that augments real-image nnU-Net training with label-to-image synthesis. Synthetic volumes are generated from cardiac label maps using contrast and acquisition perturbations calibrated to the training cohort, then mixed with real images to retain thoracic context absent from the labels (and thus the synthesized images). We model cardiac label variation through controlled changes in myocardial wall thickness and partial supervision of uncertain vessel endpoints. On the CARE Whole-Heart benchmark, synthetic-only training performs worse than the real-image nnU-Net baseline, whereas calibrated real-synthetic training improves cross-modality segmentation without changing the architecture; the improvement is larger for MRI than for CT. The results show that modifying the training data strategy can benefit model development for heterogeneous cardiac data. Code and trained weights will be released at this https URL.
https://arxiv.org/abs/2608.31073
Language is humanity's most consequential technology, yet for over a billion speakers across India's twenty-two constitutionally recognised languages, its digital layer remains structurally incomplete. Named Entity Recognition (NER), the foundational step in transforming raw text into machine-interpretable knowledge, has been studied exhaustively for English but remains largely unsolved across most Indic languages. This paper presents a rigorous comparative study of generative and encoder-based neural architectures for NER on all eleven languages of the Naamapadam benchmark. We evaluate five classic model families spanning sequence-to-sequence transformers and multilingual encoders; four decoder-only large language models (LLMs) fine-tuned with LoRA and 4-bit NF4 quantisation; and nine generative models in zero-to-5-shot inference. Under strict CoNLL span-level evaluation, encoder-based models (mBERT and XLM-R, both F1=0.675 on Hindi) substantially outperform every generative architecture in ten of eleven languages, with gaps of 7.5-40 percentage points against the strongest competitor (Gemma-2-2B: avg F1=0.427). The best few-shot result reaches only 28% of the encoder baseline. We identify three language clusters--encoder-dominant, partial-coverage, and failure-zone; and provide actionable deployment guidelines grounded in transfer learning and low-resource NLP principles.
https://arxiv.org/abs/2608.29959
Diabetic retinopathy (DR) is a major cause of preventable blindness, creating a need for accurate and trustworthy automated screening. This study investigates an explainable DR classification framework using vision foundation models and multiple transfer learning strategies. Three backbones, DINOv2, CLIP, and Vision Transformer (ViT), were evaluated using full fine-tuning, linear probing, and Low-Rank Adaptation (LoRA). Models were trained and internally evaluated on the ODIR dataset and externally evaluated on APTOS to assess generalization. DINOv2-LoRA achieved the highest internal AUROC of 0.758, while DINOv2 full fine-tuning and ViT full fine-tuning achieved the highest external AUROC of 0.920. Calibration was further assessed using reliability analysis after isotonic regression. For explainability, Grad-CAM and HiResCAM were evaluated against expert-annotated lesion masks from the IDRiD dataset using Dice, Intersection over Union (IoU), and Pointing Game metrics. The results demonstrate that foundation models, particularly DINOv2, can provide strong predictive performance, while LoRA offers a parameter-efficient alternative to full fine-tuning. Quantitative evaluation of explanation maps further supports the assessment of whether model attention corresponds to clinically relevant retinal lesions.
https://arxiv.org/abs/2608.28207
Mixture-of-Experts (MoE) scales language models by routing each input through a small set of independently parameterized experts. We show that copying this design into convolutional networks fails for a structural reason: parallel convolutional experts that read the same input channels learn nearly identical filters. We therefore move the expert axis from operator duplication to channel selection. We introduce Mixture of Channel Experts (MoCE), a structured sparse channel-mixing layer, inspired by MoE, that replaces pointwise (1x1) channel-reduction projections. In MoCE, an expert is a single output channel with a learned sparse support of k << C input channels. The selected channels are combined by a softmax whose temperature is predicted per input, so each expert can move between mean-like and max-like aggregation. A residual expert summarizes the unselected channels, and a load-balancing loss keeps channel coverage complete. MoCE replaces a dense projection whose cost is quadratic in C with a mechanism whose relative cost scales as k/C, and the predicted savings hold in measured wall-clock time. Across ResNet backbones on ImageNet-1K and CIFAR-100, transfer learning, EfficientViT, and a strong modern training recipe, MoCE matches or exceeds dense baselines and prior channel-selection methods while reducing MACs by 16.7% and end-to-end latency.
https://arxiv.org/abs/2608.23794